Last update
3/31/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.3
USERS' SCORE
Good
Based on 3 Reviews
8.6
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Vitamin E (as D-alpha tocopheryl succinate)
20.1 mg
134%
Selenium (as Se-Methyl L-Selenocysteine, L-selenomethionine (yeast-free), sodium selenite)
200 mcg
364%
Top Medical Research Studies
8
This study focused on how selenium-loaded porous silica nanospheres (Se@PSN) could help repair the heart following a myocardial infarction (MI). These tiny particles are designed to neutralize harmful molecules called reactive oxygen species, which play a significant role in heart damage during MI.
We found that Se@PSN not only reduces cellular damage but also promotes the production of protective antioxidant proteins. By enhancing mitochondrial function, these nanospheres could potentially preserve heart function after an MI, demonstrating promising results for future treatments.
We found that Se@PSN not only reduces cellular damage but also promotes the production of protective antioxidant proteins. By enhancing mitochondrial function, these nanospheres could potentially preserve heart function after an MI, demonstrating promising results for future treatments.
Read More
8
We investigated how long-term exposure to urban air pollution affects the recovery from ischemic stroke in mice. Our findings showed that breathing in fine particulate matter increases neuroinflammation and cardiac injury, leading to higher mortality rates after a stroke.
Interestingly, incorporating a vitamin E-rich diet helped reduce cardiac damage and lung inflammation caused by this exposure. We saw a noteworthy improvement in survival rates among mice with ischemic strokes who received the vitamin E, highlighting its potential protective effects against the dangers of urban air pollution.
Interestingly, incorporating a vitamin E-rich diet helped reduce cardiac damage and lung inflammation caused by this exposure. We saw a noteworthy improvement in survival rates among mice with ischemic strokes who received the vitamin E, highlighting its potential protective effects against the dangers of urban air pollution.
Read More
8
Vitamin E intake and heart health
We investigated how dietary vitamin E intake relates to cardiovascular disease and mortality using data from over 39,000 participants in the NHANES study from 2003 to 2018.
Our findings showed that people with higher vitamin E consumption had a significantly lower risk of developing cardiovascular disease and reduced all-cause mortality.
Specifically, those consuming more than 9.86 mg of vitamin E were associated with a 43% lower odds of cardiovascular issues compared to those with lower intakes. Yet, results for cardiovascular-related deaths showed less certainty.
This suggests that including vitamin E-rich foods in our diets could have positive effects on heart health and longevity.
Our findings showed that people with higher vitamin E consumption had a significantly lower risk of developing cardiovascular disease and reduced all-cause mortality.
Specifically, those consuming more than 9.86 mg of vitamin E were associated with a 43% lower odds of cardiovascular issues compared to those with lower intakes. Yet, results for cardiovascular-related deaths showed less certainty.
This suggests that including vitamin E-rich foods in our diets could have positive effects on heart health and longevity.
Read More
Most Useful Reviews
9
Excellent antioxidant
1 people found this helpful
Selenium is crucial for healthy heart function, thyroid health, and immunity. Under my endocrinologist's guidance, I've consistently taken selenium courses, yielding excellent results without hormone therapy. It serves as a potent antioxidant, enhancing vitality and promoting youthfulness.
Read More
9
Strengthens cardiovascular function
This selenium supplement, along with Vitamin E for better absorption, offers daily dosage support. Selenium stimulates metabolic functions, protects against cardiovascular disease, and enhances mental activity. It is crucial for proper thyroid gland functioning and bolsters the immune system.
Read More
9
Vital for cardiovascular protection
I always have selenium in my medicine cabinet since it’s crucial for preventing disease. A doctor highlighted its importance, especially for supporting thyroid health, as many people now suffer from selenium deficiency.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.3
- All Researches
9
Selenium nanoparticles aid heart recovery
Our exploration focused on the potential of selenium nanoparticles (SeNPs) to reduce damage from ischemia/reperfusion injury, a common aftermath of heart attacks. We found that these SeNPs, introduced through intravenous injection, demonstrated powerful antioxidant and anti-inflammatory effects.
By disrupting a harmful cellular cycle, they protected heart cells and minimized inflammation. In tests, SeNPs not only improved heart function but also decreased cell death and tissue scarring. These findings suggest that selenium nanoparticles could be a valuable addition to heart attack treatments.
By disrupting a harmful cellular cycle, they protected heart cells and minimized inflammation. In tests, SeNPs not only improved heart function but also decreased cell death and tissue scarring. These findings suggest that selenium nanoparticles could be a valuable addition to heart attack treatments.
Read More
9
We explored the potential of selenium-doped copper formate (Cuf-Se) nanozymes in treating atherosclerosis, a key contributor to cardiovascular diseases. By targeting inflammation and oxidative stress, Cuf-Se shows promise by reducing reactive oxygen species and preventing the formation of foam cells.
Although this study primarily tests the effectiveness in mice, findings indicate a notable reduction in plaque formation and inflammation. Cuf-Se led to a five-fold decrease in plaque area, highlighting its potential as a novel treatment strategy for atherosclerosis.
Although this study primarily tests the effectiveness in mice, findings indicate a notable reduction in plaque formation and inflammation. Cuf-Se led to a five-fold decrease in plaque area, highlighting its potential as a novel treatment strategy for atherosclerosis.
Read More
8
Dietary antioxidants reduce mortality risk
We evaluated how dietary antioxidants, including vitamins like C and E, affect mortality risks in individuals with cardiovascular disease (CVD). Our analysis incorporated data from nearly 1,400 participants, using advanced statistical models to determine the connections between antioxidant intake and death rates.
The findings showed that higher levels of dietary antioxidants correlate with a lower risk of dying from CVD. Specifically, those in the highest antioxidant consumption group had significantly reduced mortality risks compared to those with lower intake. This points to the potential benefits of increasing antioxidants in the diet for better health outcomes in those managing CVD.
The findings showed that higher levels of dietary antioxidants correlate with a lower risk of dying from CVD. Specifically, those in the highest antioxidant consumption group had significantly reduced mortality risks compared to those with lower intake. This points to the potential benefits of increasing antioxidants in the diet for better health outcomes in those managing CVD.
Read More
8
This study focused on how selenium-loaded porous silica nanospheres (Se@PSN) could help repair the heart following a myocardial infarction (MI). These tiny particles are designed to neutralize harmful molecules called reactive oxygen species, which play a significant role in heart damage during MI.
We found that Se@PSN not only reduces cellular damage but also promotes the production of protective antioxidant proteins. By enhancing mitochondrial function, these nanospheres could potentially preserve heart function after an MI, demonstrating promising results for future treatments.
We found that Se@PSN not only reduces cellular damage but also promotes the production of protective antioxidant proteins. By enhancing mitochondrial function, these nanospheres could potentially preserve heart function after an MI, demonstrating promising results for future treatments.
Read More
8
Selenium nanoparticles show heart benefits
We evaluated the use of selenium-quantum-dot-loaded silica nanoparticles as a new treatment for myocardial ischemia-reperfusion injury, a serious cardiovascular issue. These nanoparticles showed impressive abilities to scavenge harmful reactive oxygen species and improve heart cell function.
While traditional therapies struggle to target key problems like ferroptosis, the selenium nanoparticles effectively reduced this damage and preserved mitochondrial integrity. Our findings suggest that these nanoparticles could significantly lower heart damage and inflammation, bringing us closer to better treatment options for heart conditions.
While traditional therapies struggle to target key problems like ferroptosis, the selenium nanoparticles effectively reduced this damage and preserved mitochondrial integrity. Our findings suggest that these nanoparticles could significantly lower heart damage and inflammation, bringing us closer to better treatment options for heart conditions.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Excellent antioxidant
1 people found this helpful
Selenium is crucial for healthy heart function, thyroid health, and immunity. Under my endocrinologist's guidance, I've consistently taken selenium courses, yielding excellent results without hormone therapy. It serves as a potent antioxidant, enhancing vitality and promoting youthfulness.
Read More
9
Strengthens cardiovascular function
This selenium supplement, along with Vitamin E for better absorption, offers daily dosage support. Selenium stimulates metabolic functions, protects against cardiovascular disease, and enhances mental activity. It is crucial for proper thyroid gland functioning and bolsters the immune system.
Read More
9
Vital for cardiovascular protection
I always have selenium in my medicine cabinet since it’s crucial for preventing disease. A doctor highlighted its importance, especially for supporting thyroid health, as many people now suffer from selenium deficiency.
Read More
Frequently Asked Questions
9
Excellent antioxidant
1 people found this helpful
Selenium is crucial for healthy heart function, thyroid health, and immunity. Under my endocrinologist's guidance, I've consistently taken selenium courses, yielding excellent results without hormone therapy. It serves as a potent antioxidant, enhancing vitality and promoting youthfulness.
9
Strengthens cardiovascular function
This selenium supplement, along with Vitamin E for better absorption, offers daily dosage support. Selenium stimulates metabolic functions, protects against cardiovascular disease, and enhances mental activity. It is crucial for proper thyroid gland functioning and bolsters the immune system.
8
Dietary antioxidants reduce mortality risk
We evaluated how dietary antioxidants, including vitamins like C and E, affect mortality risks in individuals with cardiovascular disease (CVD). Our analysis incorporated data from nearly 1,400 participants, using advanced statistical models to determine the connections between antioxidant intake and death rates.
The findings showed that higher levels of dietary antioxidants correlate with a lower risk of dying from CVD. Specifically, those in the highest antioxidant consumption group had significantly reduced mortality risks compared to those with lower intake. This points to the potential benefits of increasing antioxidants in the diet for better health outcomes in those managing CVD.
The findings showed that higher levels of dietary antioxidants correlate with a lower risk of dying from CVD. Specifically, those in the highest antioxidant consumption group had significantly reduced mortality risks compared to those with lower intake. This points to the potential benefits of increasing antioxidants in the diet for better health outcomes in those managing CVD.
7
This population-based study involved over 16,000 adults with hypertension to explore how dietary antioxidants like selenium impact mortality rates. By tracking participants for nearly eight years, we discovered that those with the highest intake of antioxidants showed a significantly lower risk of dying from any cause or cardiovascular disease.
Specifically, selenium appeared beneficial, suggesting it might play a role in improving health outcomes for those with hypertension. However, further research, particularly randomized controlled trials, is essential to confirm these valuable insights.
Specifically, selenium appeared beneficial, suggesting it might play a role in improving health outcomes for those with hypertension. However, further research, particularly randomized controlled trials, is essential to confirm these valuable insights.
9
Selenium nanoparticles aid heart recovery
Our exploration focused on the potential of selenium nanoparticles (SeNPs) to reduce damage from ischemia/reperfusion injury, a common aftermath of heart attacks. We found that these SeNPs, introduced through intravenous injection, demonstrated powerful antioxidant and anti-inflammatory effects.
By disrupting a harmful cellular cycle, they protected heart cells and minimized inflammation. In tests, SeNPs not only improved heart function but also decreased cell death and tissue scarring. These findings suggest that selenium nanoparticles could be a valuable addition to heart attack treatments.
By disrupting a harmful cellular cycle, they protected heart cells and minimized inflammation. In tests, SeNPs not only improved heart function but also decreased cell death and tissue scarring. These findings suggest that selenium nanoparticles could be a valuable addition to heart attack treatments.
8
Selenium nanoparticles show heart benefits
We evaluated the use of selenium-quantum-dot-loaded silica nanoparticles as a new treatment for myocardial ischemia-reperfusion injury, a serious cardiovascular issue. These nanoparticles showed impressive abilities to scavenge harmful reactive oxygen species and improve heart cell function.
While traditional therapies struggle to target key problems like ferroptosis, the selenium nanoparticles effectively reduced this damage and preserved mitochondrial integrity. Our findings suggest that these nanoparticles could significantly lower heart damage and inflammation, bringing us closer to better treatment options for heart conditions.
While traditional therapies struggle to target key problems like ferroptosis, the selenium nanoparticles effectively reduced this damage and preserved mitochondrial integrity. Our findings suggest that these nanoparticles could significantly lower heart damage and inflammation, bringing us closer to better treatment options for heart conditions.
2
We explored how certain antioxidants, especially vitamin E (α-tocopherol), relate to cardiovascular disease risk using a two-sample Mendelian randomization approach.
Surprisingly, our findings suggest that higher levels of α-tocopherol might be associated with an increased risk of serious heart conditions like myocardial infarction and arrhythmias.
Similarly, retinol was linked to greater risks for cardiomyopathy and heart failure. This challenges the common perception of antioxidants as solely beneficial, indicating that some may actually pose health risks.
More research is needed to fully understand these relationships and their implications for our dietary choices.
Surprisingly, our findings suggest that higher levels of α-tocopherol might be associated with an increased risk of serious heart conditions like myocardial infarction and arrhythmias.
Similarly, retinol was linked to greater risks for cardiomyopathy and heart failure. This challenges the common perception of antioxidants as solely beneficial, indicating that some may actually pose health risks.
More research is needed to fully understand these relationships and their implications for our dietary choices.
References
- Hu X, Zhao Z, An Q, Li Y, Wang B. Association of independent dietary antioxidant intake, and CDAI level with risks of all-cause and cardiovascular-cause death among population with cardiovascular disease. BMC Public Health. 2025;25:1327. 10.1186/s12889-025-22481-1
- Li T, Liu X, Yang B, Wang Z, Chen Y, et al. Selenium-loaded porous silica nanospheres improve cardiac repair after myocardial infarction by enhancing antioxidant activity and mitophagy. Free Radic Biol Med. 2025;232:292. 10.1016/j.freeradbiomed.2025.03.004
- Li T, Yang B, Liu X, Shi D, Wang Z, et al. Silica Nanoparticles Loaded With Selenium Quantum Dots Reduce Myocardial Ischemia-Reperfusion Injury by Alleviating Ferroptosis and Mitochondrial Dysfunction. Int J Nanomedicine. 2025;20:1843. 10.2147/IJN.S500810
- Chen C, Ma J, Duan S, Xue M, Yang Z, et al. Mitigation of ischemia/reperfusion injury via selenium nanoparticles: Suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation. Biomaterials. 2025;318:123119. 10.1016/j.biomaterials.2025.123119
- Zhao S, Cao Y, Liu H, Liu A. Joint and independent associations of dietary antioxidant intakes with all-cause and cardiovascular mortality among patients with hypertension: a population-based cohort study. Nutr J. 2025;24:14. 10.1186/s12937-024-01062-9
- Huang X, Zhou Y, Guo Y, Yan D, Sun P, et al. Selenium-Doped Copper Formate Nanozymes with Antisenescence and Oxidative Stress Reduction for Atherosclerosis Treatment. Nano Lett. 2025;25:2662. 10.1021/acs.nanolett.4c05348
- Li B, Liu H, Mishra D, Yuan Z, Zhang Y, et al. The association between blood metals and cardiovascular diseases: findings from National Health and Nutrition Examination Survey 2011-2020. Front Cardiovasc Med. 2024;11:1479665. 10.3389/fcvm.2024.1479665
- Li X, Liu W, Jin T, Zhang T. Diet-derived circulating antioxidants and functional outcome after ischemic stroke: Evidence from genetic studies. J Stroke Cerebrovasc Dis. 2024;33:108039. 10.1016/j.jstrokecerebrovasdis.2024.108039
- Yang R, Lv M, Yang X, Zhai S. A Mendelian randomized study of circulating antioxidants in the diet and risk of cardiovascular disease. Sci Rep. 2025;15:10341. 10.1038/s41598-025-94369-4
- Czlapka-Matyasik M, Wadolowska L, Gut P, Gramza-Michałowska A. Changes in Oxidative Stress, Inflammatory Markers, and Lipid Profile After a 6-Week High-Antioxidant-Capacity Dietary Intervention in CVD Patients. Nutrients. 2025;17. 10.3390/nu17050806
- Ishihara N, Tanaka M, Namba K, Kawano S, Nishimura S, et al. Long-term exposure to urban particulate matter exacerbates mortality after ischemic stroke in mice. J Toxicol Sci. 2025;50:147. 10.2131/jts.50.147
- Zeng Q, Liao M, Li Y, She F, Zhang P. Association between dietary vitamin E intake and incident cardiovascular disease, cardiovascular, and all-cause mortality: A prospective cohort study using NHANES 2003-2018 data. Int J Cardiol Cardiovasc Risk Prev. 2025;24:200340. 10.1016/j.ijcrp.2024.200340
- Ren W, Li Y, Lu C, Liu S, Shao Y, et al. Comprehensive assessment on the association of dietary vitamins with all-cause and cardiovascular mortality among individuals with prediabetes: evidence from NHANES 1999-2018. Food Funct. 2024;15:10037. 10.1039/d4fo02893g
- Li B, Hu M, Ma Y, Sun X, Wu D, et al. Association between Vitamin E, Vitamin B6, and Vitamin B12 with coronary heart disease. Sci Rep. 2024;14:19960. 10.1038/s41598-024-68413-8
- Wang Y, Han L, Ling S, Sha Y, Sun H. Dietary intake of potassium, vitamin E, and vitamin C emerges as the most significant predictors of cardiovascular disease risk in adults. Medicine (Baltimore). 2024;103:e39180. 10.1097/MD.0000000000039180
- Rafique S, Khan DA, Farhat K, Khan MA, Noor M, et al. Comparative efficacy of tocotrienol and tocopherol (vitamin E) on atherosclerotic cardiovascular diseases in humans. J Pak Med Assoc. 2024;74:1124. 10.47391/JPMA.9227
- Sun Y, Zhang H, Qi G, Tian W. Nutrient deficiency patterns and all-cause and cardiovascular mortality in older adults with hypertension: a latent class analysis. BMC Public Health. 2024;24:1551. 10.1186/s12889-024-19003-w
- Masle AM, Kibel A, Jukić I, Čičak P, Selthofer-Relatić K, et al. Enhancing Endothelial Function with Nutrient-Enriched Table Hen Eggs: A Randomized Study in Patients Recovering from Acute Coronary Syndrome. Clin Interv Aging. 2024;19:953. 10.2147/CIA.S461821
- Yakoubi S. Synergistic integration of deep learning with protein docking in cardiovascular disease treatment strategies. IUBMB Life. 2024;76:666. 10.1002/iub.2819
- Liu C, Liang D. Association between Dietary Vitamin E Intake and the Risk of Hypertension in US Adults. Curr Vasc Pharmacol. 2024;22:391. 10.2174/0115701611297956240425115501
Data last updated:
